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    Related Topics

    From Lymphatic System

    Lateral Axillary Nodes
    Located along the humerus in the axilla.
    Pectoral Axillary Nodes
    Located along the anterior chest wall.
    Jugular Trunk
    Drains lymph from the head and neck.
    Lingual Tonsils
    Located at the base of the tongue.
    Lymph Nodes
    Small structures that filter lymph and store immune cells.
    Red Bone Marrow
    Produces lymphocytes; site of B-cell maturation.
    Mastoid Lymph Nodes
    Drain the posterior scalp and ear.
    Paratracheal Nodes
    Located lateral to the trachea.
    NALT
    Nasal-associated lymphoid tissue.
    Submental Lymph Nodes
    Drain the floor of the mouth and central lower lip.
    Parotid Lymph Nodes
    Drain the lateral face and scalp.
    Anterior Mediastinal Nodes
    Drain anterior thoracic structures.
    Mesenteric Lymph Nodes
    Drain the intestines and abdominal structures.
    Palatine Tonsils
    Located on each side of the oropharynx.
    Subclavian Trunk
    Drains lymph from the upper limbs.
    Right Lymphatic Duct
    Drains right upper quadrant of the body.
    GALT
    Gut-associated lymphoid tissue.
    Sacral Lymph Nodes
    Drain the pelvic floor and rectum.
    Cisterna Chyli
    Dilated sac at the start of the thoracic duct.
    Spleen
    Filters blood and initiates immune response.
    Lymphatic Capillaries
    Initial lymphatic vessels that collect interstitial fluid.
    Posterior Mediastinal Nodes
    Drain posterior thoracic structures.
    Pretracheal Nodes
    Located anterior to the trachea.
    BALT
    Bronchus-associated lymphoid tissue.
    Thymus
    Primary lymphoid organ for T-cell maturation.

    Bronchomediastinal Trunk

    Reviewed by our medical team

    Drains lymph from thoracic organs.

    1. Overview

    The bronchomediastinal trunks are paired lymphatic vessels—right and left—that drain lymph from the thoracic viscera and mediastinal structures. They serve as major conduits for lymph from the lungs, heart, thymus, trachea, and associated lymph nodes. These trunks connect regional thoracic lymphatic drainage to the systemic circulation by channeling lymph into either the right lymphatic duct, the thoracic duct, or directly into the subclavian veins.

    2. Location

    The bronchomediastinal trunks are located in the superior and middle mediastinum, one on each side of the thorax. Their formation and terminal drainage points are as follows:

    • Right bronchomediastinal trunk:

      • Formed by efferent lymphatics from the right hilar (bronchopulmonary), tracheobronchial, and paratracheal lymph nodes

      • Usually drains into the right lymphatic duct or directly into the junction of the right subclavian and internal jugular veins

    • Left bronchomediastinal trunk:

      • Receives lymph from the left hilar nodes, left tracheobronchial nodes, and nearby mediastinal structures

      • Usually drains into the thoracic duct, which then empties into the left venous angle

    3. Structure

    The bronchomediastinal trunks are thin-walled lymphatic vessels that resemble small veins in structure. Their key components include:

    • Endothelium: A single layer of endothelial cells that allows for selective passage of lymph

    • Valves: Present to ensure one-way flow of lymph toward the venous system

    • Connective tissue and smooth muscle: Thin layers support contraction and regulation of flow

    The trunks do not pass through any additional lymph nodes, but rather collect lymph from terminal efferent vessels of nodal chains in the thorax.

    4. Function

    The bronchomediastinal trunks serve as the primary pathways for lymph exiting the thoracic lymph nodes. Their main functions include:

    • Lymph drainage: Carry lymph from the lungs, bronchi, heart, thymus, trachea, esophagus, and mediastinal lymph nodes to the venous system

    • Immune cell transport: Convey lymphocytes and antigen-presenting cells from thoracic tissues into systemic circulation

    • Fluid balance maintenance: Return excess interstitial fluid from the thoracic region back into the bloodstream

    5. Physiological Role(s)

    In addition to their drainage role, the bronchomediastinal trunks contribute to systemic physiology and immunity:

    • Respiratory immune surveillance: Facilitate rapid immune response to inhaled pathogens through their connection to bronchopulmonary and tracheobronchial lymph nodes

    • Cardiac and thymic monitoring: Drain lymph from the heart and thymus, assisting in immune modulation and self-tolerance

    • Coordination with major lymphatic ducts: Integrate the thoracic lymphatic flow into the larger systemic return loop through the thoracic duct or right lymphatic duct

    6. Clinical Significance

    Lymphatic Obstruction

    Obstruction or compression of the bronchomediastinal trunks may result from:

    • Enlarged lymph nodes due to lymphoma, tuberculosis, or sarcoidosis

    • Mediastinal tumors (e.g., thymoma, bronchogenic carcinoma)

    • Post-radiation fibrosis

    This can impair lymphatic drainage, potentially leading to thoracic lymphedema or impaired immune cell transport.

    Cancer Metastasis and Staging

    Since the bronchomediastinal trunks drain lymph from the lungs and mediastinum, they are key in understanding lung cancer staging and metastasis:

    • Involvement of hilar or mediastinal lymph nodes can indicate spread toward or beyond these trunks

    • Evaluation of lymphatic spread often requires imaging (CT, PET-CT) and biopsy of nodes feeding into the trunks

    Chylothorax (Rare Involvement)

    Although more commonly associated with thoracic duct injury, trauma or obstruction of the bronchomediastinal trunks could contribute to chylous effusion in rare cases, particularly on the right side. This may occur post-surgery or with central venous catheterization.

    Role in Immune Disorders

    Chronic inflammatory diseases like sarcoidosis and tuberculosis often involve mediastinal lymphadenopathy, which can lead to congestion or dysfunction in the bronchomediastinal trunks, influencing thoracic immune regulation and drainage patterns.

    Diagnostic Importance

    Evaluation of bronchomediastinal drainage often includes:

    • Imaging: CT or PET-CT to assess lymph node size and activity

    • Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): For sampling tracheobronchial and paratracheal nodes

    Assessment is critical in the workup of lung cancer, lymphoma, and chronic infections.

    Did you know? The thymus is where T-cells, a type of white blood cell, mature and become active in the immune response.