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    Related Topics

    From Digestive System

    Lingual Frenulum
    Fold of mucous membrane anchoring the tongue to the floor of the mouth.
    Rectum
    Straight section of the colon leading to anus.
    Upper Esophageal Sphincter
    Muscle ring that controls entry into the esophagus.
    Right Lobe
    Larger functional lobe of the liver.
    Teeth
    Structures in the jaws for mechanical breakdown of food.
    Tail of Pancreas
    Tapered end of pancreas near spleen.
    Ligamentum Venosum
    Remnant of ductus venosus in liver.
    Body of Pancreas
    Central elongated portion of pancreas.
    Vermiform Appendix
    Worm-like appendage of the cecum.
    Greater Omentum
    Fatty fold of peritoneum covering intestines.
    Sublingual Glands
    Salivary glands beneath the tongue.
    Caudate Lobe
    Lobe of liver near inferior vena cava.
    External Anal Sphincter
    Voluntary muscle around anus.
    Oral Cavity
    Entry point of the digestive system; includes teeth, tongue, and salivary openings.
    Descending Colon
    Vertical segment of the colon on the left side.
    Round Ligament of Liver
    Remnant of fetal umbilical vein.
    Liver
    Largest gland in the body with roles in metabolism and bile production.
    Haustra
    Pouch-like segments of colon.
    Nasopharynx
    Superior region of pharynx behind the nasal cavity.
    Parotid Glands
    Largest salivary glands located near the ear.
    Left Lobe
    Smaller lobe of the liver.
    Rugae of Stomach
    Internal folds allowing expansion of the stomach.
    Epiploic Appendages
    Fat-filled pouches attached to colon.
    Cardia
    Upper opening of the stomach.
    Palatine Tonsils
    Lymphatic tissues on either side of the oropharynx.

    Splenic Flexure

    Reviewed by our medical team

    Bend between transverse and descending colon.

    Overview

    The splenic flexure, also known as the left colic flexure, is a sharp bend in the colon where the transverse colon transitions into the descending colon. It marks a key anatomical and physiological transition point in the large intestine, associated with changes in blood supply and innervation. It is named for its proximity to the spleen.

    Location

    The splenic flexure is located in the left upper quadrant (LUQ) of the abdomen. More specifically, it:

    • Lies beneath the spleen, near the tip of the 9th or 10th rib

    • Is positioned posterior to the stomach and anterior to the left kidney

    • Marks the junction between the midgut and hindgut embryologically

    It is more superior and sharply angled than the right (hepatic) flexure, making it more fixed and less mobile.

    Structure

    The splenic flexure is structurally a continuation of the colonic wall but has unique anatomical considerations:

    • Serosal covering: Intraperitoneal, suspended by the phrenicocolic ligament and adjacent to the splenocolic ligament

    • Wall layers: Mucosa, submucosa, muscularis externa, and serosa—consistent with the rest of the colon

    • Vascular supply: Dual blood supply from both the superior mesenteric artery (SMA) via the middle colic branch and the inferior mesenteric artery (IMA) via the left colic branch

    • Lymphatic drainage: Drains into the inferior mesenteric and para-aortic lymph nodes

    Function

    The splenic flexure contributes to the colon’s overall function of:

    • Transporting fecal material: Facilitates the transition of intestinal contents from the transverse colon to the descending colon

    • Absorption: Continues absorption of water, electrolytes, and vitamins produced by colonic bacteria

    • Fermentation: Supports microbial fermentation of undigested material

    Physiological Role(s)

    Though not functionally distinct, the splenic flexure plays roles in:

    • Segmental contraction: Assists in forming and moving feces via haustral and mass movements

    • Transitional physiology: Reflects a shift in autonomic innervation—from vagus nerve (midgut) to pelvic splanchnic nerves (hindgut)

    • Vascular watershed area: Located at the border of SMA and IMA territories, making it vulnerable to ischemia

    Clinical Significance

    The splenic flexure is clinically important for several reasons:

    • Ischemic colitis: It is a known “watershed area” with reduced collateral circulation, making it susceptible to ischemia during hypoperfusion states

    • Splenic flexure syndrome: A functional gastrointestinal disorder characterized by bloating, cramping, and left upper quadrant pain due to trapped gas or colonic spasm

    • Colorectal cancer: Tumors may arise at the splenic flexure and are often more challenging surgically due to the sharp angle and dual blood supply

    • Endoscopic navigation: The flexure may be difficult to pass during colonoscopy due to its fixed and angulated position

    • Referred pain: Disorders here may cause referred pain to the left upper abdomen or back

    Imaging studies such as CT, barium enema, and colonoscopy help evaluate pathology at the splenic flexure. Awareness of its vascular vulnerability and fixed location is essential in both medical and surgical gastroenterology.

    Did you know? The stomach acid is strong enough to dissolve metal, but the stomach lining protects itself from being digested!