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From Digestive System
Peritoneum
Serous membrane lining the abdominal cavity.
Overview
The peritoneum is a continuous, thin, and transparent serous membrane that lines the walls of the abdominal cavity and covers most of the abdominal organs. It forms a complex, slippery surface that facilitates movement, supports organs, and serves as a conduit for blood vessels, lymphatics, and nerves. The peritoneum is divided into two main layers: the parietal peritoneum and the visceral peritoneum.
Location
The peritoneum resides in the abdominal and pelvic cavities. It:
Parietal peritoneum: Lines the internal surface of the abdominal wall
Visceral peritoneum: Covers the outer surfaces of most abdominal organs, including the stomach, intestines, and liver
Encloses the peritoneal cavity, a potential space between the two layers filled with a small amount of lubricating serous fluid
It creates structures such as the mesentery, omentum, and ligaments that suspend and connect organs.
Structure
The peritoneum is made up of:
Mesothelium: A single layer of flat, squamous epithelial cells that secrete serous fluid
Underlying connective tissue: Contains blood vessels, lymphatics, and nerves
Two continuous layers:
Parietal peritoneum: Sensitive to pressure, pain, and temperature; innervated by somatic nerves
Visceral peritoneum: Less sensitive; innervated by autonomic nerves and sensitive to stretch or ischemia
The peritoneal cavity is a closed sac in males and open to the external environment in females via the uterine tubes.
Function
The peritoneum serves several vital roles:
Lubrication: Secretes serous fluid to reduce friction between moving organs
Support: Helps maintain the position of abdominal organs
Pathway for neurovascular supply: Blood vessels, nerves, and lymphatics travel within peritoneal folds to reach the organs
Fat storage: Especially in the greater omentum, which contains abundant adipose tissue
Physiological Role(s)
The peritoneum plays dynamic physiological roles:
Immunologic function: Contains macrophages and lymphocytes that respond to infection or inflammation
Absorptive properties: Can absorb fluids, drugs (e.g., via peritoneal dialysis), and local inflammatory mediators
Barrier function: Localizes infections (e.g., in appendicitis) by forming adhesions and walls off affected areas
Healing response: Supports rapid tissue repair following injury or inflammation
Clinical Significance
The peritoneum is frequently involved in various clinical conditions:
Peritonitis: Inflammation of the peritoneum, usually due to infection (e.g., ruptured appendix); can be life-threatening and requires urgent treatment
Ascites: Accumulation of fluid in the peritoneal cavity, commonly seen in liver cirrhosis, malignancy, or heart failure
Peritoneal carcinomatosis: Widespread cancer spread within the peritoneum, often from gastrointestinal or ovarian cancers
Adhesions: Fibrous bands formed after surgery or inflammation, which can cause bowel obstruction
Peritoneal dialysis: A treatment for renal failure where the peritoneum acts as a semipermeable membrane for waste exchange
Hernias: Protrusion of abdominal contents through weak spots in the abdominal wall, often involving peritoneal sacs
The peritoneum is visualized and assessed using imaging modalities like ultrasound, CT, and diagnostic laparoscopy, especially in abdominal emergencies or oncologic evaluations.
Did you know? The large intestine absorbs water, and the remaining material is turned into waste for elimination.